Research output 📄

Publications

A collection of my peer-reviewed research — spanning radiomics, PET imaging, oncology, and systematic reviews. My work has since moved to the public health level, but this is where it started.

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Journal Articles

On the robustness of [18F]-FDG-PET radiomic features to variations in image acquisition and reconstruction settings: A phantom study

Ramlee, S., Delgado-Ortet, M., Escudero Sanchez, L., Aloj, L., & Manavaki, R.

PLOS ONE2025Vol. 20(10): e0335219

Using the NEMA-IQ phantom, evaluates the robustness of [18F]-FDG-PET radiomic features to variations in acquisition duration, reconstruction algorithm, matrix size, and other parameters — finding that most features are not robust and that simple mathematical corrections have limited effectiveness.

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Mitigating the impact of image processing variations on tumour [18F]-FDG-PET radiomic feature robustness

Ramlee, S., Manavaki, R., Aloj, L., & Escudero Sanchez, L.

Scientific Reports2024Nature Portfolio

Investigates how variations in image processing parameters affect the robustness of [18F]-FDG PET radiomic features, demonstrating that applying parameter range conditions and mathematical corrections can meaningfully improve feature robustness in clinical settings.

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Introduction to radiomics for a clinical audience

McCague, C., Ramlee, S., Reinius, M., Selby, I., Hulse, D., Piyatissa, P., Bura, V., Crispin-Ortuzar, M., Sala, E., & Woitek, R.

Clinical Radiology2023Vol. 78(2): 83–98

A comprehensive introductory review of radiomics for clinicians — covering its process pipeline, key cancer studies, challenges, wider clinical applications, and anticipated future impact on radiology practice.

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Radiomic signatures associated with CD8+ tumour-infiltrating lymphocytes: a systematic review and quality assessment study

Ramlee, S., Hulse, D., Bernatowicz, K., Pérez-López, R., Sala, E., & Aloj, L.

Cancers2022Vol. 14(15)

Systematically reviews studies linking radiomic features with CD8+ tumour-infiltrating lymphocytes. Finds limited generalisability of results and overall low study quality — highlighting the need for standardised methodology in the field.

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Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review

Bolland, H., Ma, T. S., Ramlee, S., Ramadan, K., & Hammond, E. M.

Biochemical Society Transactions2021Vol. 49(3): 1251–1263

Identifies and discusses potential molecular links between the DNA damage response and unfolded protein response under radiobiological hypoxia — highlighting targets for enhancing radiotherapy efficacy in poorly oxygenated tumours.

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PhD Thesis

Doctoral Thesis · University of Cambridge, United Kingdom · 2025

Towards Robust Radiomic Markers from Positron Emission Tomography in Cancer

Ramlee, Syafiq · Supervised by Luigi Aloj · DOI: 10.17863/CAM.122436

Investigates the response of [18F]-FDG PET radiomic features to various imaging parameters across three robustness studies — covering intensity discretisation, image acquisition and reconstruction, and ComBat harmonisation — with implications for the reliable use of PET radiomics in cancer healthcare.

Cambridge Repository ↗ DOI ↗

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